CD22 (CD22 molecule)

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dc.contributor.author Nyesiga, Barnabas -
dc.contributor.author El-Schich, Zahra -
dc.date.accessioned 2020-06-17T11:54:28Z
dc.date.available 2020-06-17T11:54:28Z
dc.date.issued 2020 -
dc.identifier.citation Barnabas, Nyesiga ; Zahra, El-Schich. CD22 (CD22 molecule). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2020, 12, p. 470-476 -
dc.identifier.issn 1768-3262 -
dc.identifier.uri http://hdl.handle.net/2042/70879
dc.description.abstract Sialic acid binding immunoglobulin-type lectin (Siglec) family are inhibitory receptors with diverse roles in the immune system. Siglec family contains 14 members in human and 9 in murine. Differentially expressed on various white blood cells. Here in this review we are focusing on CD22, also known as Sialic Acid-Binding Ig-Like Lectin 2 (Siglec-2). CD22 gene is located on 19q13.12 and is encoding a 140 kD type I transmembrane glycoprotein on the surface of B cells and is part of the immunoglobulin (Ig) superfamily and has been found only on B cells. CD22 has been shown to play a major role in establishing a baseline level of B-cell inhibition, and thus is a critical determinant of homeostasis in humoral immunity. en
dc.language.iso en -
dc.publisher ARMGHM - Atlas Génétique des Cancers -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; http://AtlasGeneticsOncology.org/Genes/CD22ID972ch19q13.html -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology en
dc.rights Open access resource - terms and conditions : http://irevues.inist.fr/utilisation -
dc.subject B-cell inhibition en
dc.subject CD22 en
dc.subject Sialic Acid en
dc.subject SIGLEC en
dc.subject.classification Genes Section en
dc.subject.mesh Alleles en
dc.subject.mesh Animals en
dc.subject.mesh Autoantibodies/immunology en
dc.subject.mesh Autoimmunity/*immunology en
dc.subject.mesh B-Lymphocytes/*immunology en
dc.subject.mesh Humans en
dc.subject.mesh Mice en
dc.subject.mesh Molecular Targeted Therapy en
dc.subject.mesh Polymorphism, Single Nucleotide en
dc.subject.mesh Receptors, Antigen, B-Cell/immunology en
dc.subject.mesh Sialic Acid Binding Ig-like Lectin 2/*genetics/*immunology/metabolism en
dc.subject.mesh Toll-Like Receptor 7/metabolism en
dc.subject.mesh Animals en
dc.subject.mesh Chemokines/immunology en
dc.subject.mesh Humans en
dc.subject.mesh Immunity/*immunology en
dc.subject.mesh Leukocytes/immunology en
dc.title CD22 (CD22 molecule) en
dc.type Article -
dc.contributor.affiliation Biomedical science, Health and society, Malmõ University, Malmõ, Sweden -
dc.contributor.affiliation nyesigabarnabas@gmail.com -
dc.contributor.affiliation zahra.el-schich@mau.se -
dc.identifier.doi https://doi.org/10.4267/2042/70879


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