CD22 (CD22 molecule)

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Title: CD22 (CD22 molecule)
Author: Nyesiga, Barnabas; El-Schich, Zahra
Abstract: Sialic acid binding immunoglobulin-type lectin (Siglec) family are inhibitory receptors with diverse roles in the immune system. Siglec family contains 14 members in human and 9 in murine. Differentially expressed on various white blood cells. Here in this review we are focusing on CD22, also known as Sialic Acid-Binding Ig-Like Lectin 2 (Siglec-2). CD22 gene is located on 19q13.12 and is encoding a 140 kD type I transmembrane glycoprotein on the surface of B cells and is part of the immunoglobulin (Ig) superfamily and has been found only on B cells. CD22 has been shown to play a major role in establishing a baseline level of B-cell inhibition, and thus is a critical determinant of homeostasis in humoral immunity.
Subject: B-cell inhibition; CD22; Sialic Acid; SIGLEC; Genes Section; Alleles; Animals; Autoantibodies/immunology; Autoimmunity/*immunology; B-Lymphocytes/*immunology; Humans; Mice; Molecular Targeted Therapy; Polymorphism, Single Nucleotide; Receptors, Antigen, B-Cell/immunology; Sialic Acid Binding Ig-like Lectin 2/*genetics/*immunology/metabolism; Toll-Like Receptor 7/metabolism; Animals; Chemokines/immunology; Humans; Immunity/*immunology; Leukocytes/immunology
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2020

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