TNIK (TRAF2 and NCK interacting kinase)

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Title: TNIK (TRAF2 and NCK interacting kinase)
Author: Cassaro, Adriana
Abstract: The serine/threonine kinase Traf2- and Nck interacting kinase (TNIK), is a member of the germinal center kinase (GCK) family that has been reported to have an important role in the regulation of Jun N-terminal kinase pathway (JNK) activation and actin cytoskeleton. It has also been demonstrated that TNIK is an important activator of Wnt pathway, where it interacts with β-catenin/TCF4 complex, phosphorylates Tcf4 inducing the transcription of Wnt target genes. In several studies, the expression of TNIK has been established to be involved in different human cancers.
Subject: TRAF2 and NCK interacting kinase; TCF4; beta catenin; Genes Section; Biomarkers, Tumor; Cell Line, Tumor; Gene Expression Profiling; *Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Germinal Center Kinases; Humans; Male; Molecular Targeted Therapy; Prostatic Neoplasms/drug therapy/*genetics/metabolism/pathology
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2020

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