i(3)(q10) in non-Hodgkin's lymphoma (NHL)

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URI: http://hdl.handle.net/2042/70608  |   DOI : https://doi.org/10.4267/2042/70608
Title: i(3)(q10) in non-Hodgkin's lymphoma (NHL)
Author: Zamecnikova, Adriana
Abstract: Partial or complete chromosome 3 gains resulting from the presence of trisomy 3, unbalanced translocation or isochromosome formation has been observed in different types of non-Hodgkin's lymphomas (NHL). Among them, the isochromosome of the long arm of chromosome 3 is a relatively rare chromosome aberration, associated mainly with B-cell NHL. However, its occurrence is not restricted to lymphomas, as the detection of +i(3)(q10) is considered a specific marker of polyclonal B-cell lymphocytosis with binucleated lymphocytes (PPBL) associated with an increase frequency of chromosome 3 instability as well as it may also be found in myeloid malignancies.
Subject: chromosome 3; B-cell lymphomas; T-cell lymphomas; Leukaemia Section; Antibiotics, Antineoplastic/*pharmacology; Apoptosis/drug effects; Cadherins/*genetics; Carcinogenesis/genetics; Cell Line, Tumor; Cell Survival/drug effects; *DNA Methylation; DNA Modification Methylases/antagonists & inhibitors; Down-Regulation/drug effects; Doxorubicin/*pharmacology; Gene Expression Regulation, Neoplastic/drug effects; Humans; Karyotype; Lymphoma, Non-Hodgkin/*genetics/pathology; Multiple Myeloma/*genetics/pathology; *Promoter Regions, Genetic; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor/genetics/metabolism
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2019

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