dic(7;9)(p11-13;p11)

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URI: http://hdl.handle.net/2042/70583  |   DOI : https://doi.org/10.4267/2042/70583
Title: dic(7;9)(p11-13;p11)
Author: Underdown, Mary J; Russell, Thomas B; Pettenati, Mark J; Kram, David E
Abstract: Dicentric (7;9)(p11-13;p11) is a rare but recurrent abnormality in pediatric and adult precursor B acute lymphoblastic leukemia (B-ALL). The rarity precludes a deep understanding of its biology and associated prognosis. However, recent findings have correlated dic(7;9) and PAX5 mutations, highlighting this cytogenetic event's involvement in leukemogenesis and may also shed light on the overall prognosis of dic(7;9) B-ALL.
Subject: Acute lymphoblastic leukemia; dicentric translocation; PAX5; chromosome 7; chromosome 9; Leukaemia Section; Acute Disease; Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Chromosomes/genetics; Female; Gene Rearrangement/genetics; Humans; Infant; Male; Mice; Mice, Inbred C57BL; Middle Aged; Mutation/genetics; PAX5 Transcription Factor/*genetics; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*genetics; Transcriptome/genetics; Young Adult
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2019

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