t(1;5)(q21;q32) PDE4DIP/PDGFRB::t(1;5)(q21-23;q32) TPM3/PDGFRB::t(1;5)(q21-23;q31-33)

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URI: http://hdl.handle.net/2042/70532  |   DOI : https://doi.org/10.4267/2042/70532
Title: t(1;5)(q21;q32) PDE4DIP/PDGFRB::t(1;5)(q21-23;q32) TPM3/PDGFRB::t(1;5)(q21-23;q31-33)
Author: Zamecnikova, Adriana
Abstract: Chromosomal translocations involving chromosome bands 5q31-33 that contain the gene encoding the platelet-derived growth factor beta receptor (PDGFRB) are associated with a significant minority of patients with BCR/ABL1-negative chronic myeloid neoplasms. To date, numerous PDGFRB fusion partners have been identified, with the vast majority being reported only in sporadic cases. Although PDGFRB fusions are rare, their identification is important in order to identify patients in whom targeted therapy with tyrosine kinase inhibitors is likely to be successful.
Subject: PDGFRB; PDE4DIP; TPM3; eosinophilia; myeloproliferative disorder; PDE4DIP/PDGFRB; TPM3/PDGFRB; Leukaemia Section; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor/*genetics; Female; *Gene Expression Profiling; Humans; Male; Middle Aged; Neoplasm Recurrence, Local/*genetics; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide/*genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma/classification/*genetics; Prognosis; Sequence Deletion; Young Adult; Adult; Antineoplastic Agents/therapeutic use; Benzamides; Child
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2019

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