SLC45A2 (solute carrier family 45 member 2)

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Title: SLC45A2 (solute carrier family 45 member 2)
Author: Sengupta, Mainak; Dutta, Tithi; Ray, Kunal
Abstract: SLC45A2 gene, having a chromosomal location 5p13.2, encodes a membrane associated transporter protein (MATP). MATP is a transmembrane protein. It is present in the melanosomal membrane in the melanocytes. It maintains the osmotic potential by regulating the pH of the melanosomal lumen. Defects in the SLC45A2 gene causes oculocutaneous albinism type IV; OCA IV
Subject: SLC45A2; MATP; albinism; OCA IV; Genes Section; Animals; Benzodioxoles/pharmacology/*therapeutic use; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Humans; Indolizines/pharmacology/*therapeutic use; Mice; Mice, Inbred BALB C; Neoplastic Stem Cells/*drug effects; Pancreatic Neoplasms/*drug therapy/pathology; Biomarkers, Tumor/metabolism; Carcinoma, Pancreatic Ductal/*metabolism/*mortality/pathology/therapy; Cell Nucleus/metabolism; Chemotherapy, Adjuvant; Cohort Studies; Female; Humans; Immunohistochemistry; Inhibitor of Apoptosis Proteins/*metabolism
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2019

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