BIRC5 (baculoviral IAP repeat containing 5)

Show simple item record Branco, Paola Cristina - Jimenez, Paula Christine - Machado-Neto, João Agostinho - Costa-Lotufo, Letícia Veras - 2019-10-01T14:11:54Z 2019-10-01T14:11:54Z 2019 -
dc.identifier.citation Paola Cristina, Branco ; Paula Christine, Jimenez ; João Agostinho, Machado-Neto ; Letícia Veras, Costa-Lotufo. BIRC5 (baculoviral IAP repeat containing 5). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2019, 07, p. 168-186 -
dc.identifier.issn 1768-3262
dc.description.abstract BIRC5, also known as survivin, has been implicated in cell cycle progression and apoptosis avoidance. BIRC5 is highly expressed in embryonic tissues, however very low or absent in adult tissues. BIRC5 overexpression has been frequently associated to cancer development, a poor prognosis and chemoresistance. Besides that, different BIRC5 isoforms has been characterized and related to better or worse chemotherapy responses depending on the isoform and the cancer type. So far, many efforts have been conducted in order to deplete BIRC5 in cancer cells, including gene therapy, pharmacological and nanotechnological approaches. In this review, we will discuss the role of BIRC5 in cancer cell biology and its clinical significance, demonstrating its DNA/RNA and protein aspects, also its relevance for diagnosis and prognosis, and advances as a target for the treatment of different cancer types. en
dc.language.iso en -
dc.publisher ARMGHM - Atlas Génétique des Cancers -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology en
dc.rights Open access resource - terms and conditions : -
dc.subject BIRC5 en
dc.subject Cell cycle progression en
dc.subject Apoptosis en
dc.subject Cancer en
dc.subject.classification Genes Section en
dc.subject.mesh Adolescent en
dc.subject.mesh Adult en
dc.subject.mesh Age Factors en
dc.subject.mesh Burkitt Lymphoma/*genetics en
dc.subject.mesh Child en
dc.subject.mesh Child, Preschool en
dc.subject.mesh *Chromosome Aberrations en
dc.subject.mesh Chromosomes, Human/*genetics en
dc.subject.mesh Female en
dc.subject.mesh Humans en
dc.subject.mesh Infant en
dc.subject.mesh *Loss of Heterozygosity en
dc.subject.mesh Male en
dc.subject.mesh Neoplasm Proteins/*genetics en
dc.subject.mesh Adult en
dc.subject.mesh Antineoplastic Combined Chemotherapy Protocols/*therapeutic use en
dc.subject.mesh Burkitt Lymphoma/diagnosis/*drug therapy/genetics en
dc.subject.mesh Cyclophosphamide/therapeutic use en
dc.subject.mesh Cytarabine/therapeutic use en
dc.subject.mesh Doxorubicin/therapeutic use en
dc.subject.mesh Etoposide/therapeutic use en
dc.title BIRC5 (baculoviral IAP repeat containing 5) en
dc.type Article -
dc.contributor.affiliation Department of Pharmacology, Institute of Biomedical Sciences of the University of São Paulo, São Paulo, (PCB) (JAM-N) (LVC-L) Brazil -
dc.contributor.affiliation Department of Marine Sciences, Federal University of Sao Paulo, Santos, (PCJ), Brazil -

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