PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1)

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dc.contributor.author Seza, Esin Gülce -
dc.contributor.author Güderer, Ismail -
dc.contributor.author Ermis, Çagdas -
dc.contributor.author Banerjee, Sreeparna -
dc.date.accessioned 2019-06-05T07:51:55Z
dc.date.available 2019-06-05T07:51:55Z
dc.date.issued 2019 -
dc.identifier.citation Esin Gülce, Seza ; Ismail, Güderer ; Çagdas, Ermis ; Sreeparna, Banerjee. PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2019, 5, p. 105-111 -
dc.identifier.issn 1768-3262
dc.identifier.uri http://hdl.handle.net/2042/70205
dc.description.abstract Protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1), also known as AMPK α1, is an energy sensor that plays a key role in the regulation of cellular energy metabolism. AMPK α1 is the catalytic subunit of the heterotrimeric AMPK protein with a length of 548 amino acids. A key switch to activate this protein is an alteration in the AMP/ATP ratio. The protein is dysregulated in several human diseases including diabetes and metabolic syndrome, cardiovascular diseases, neurodegenerative diseases and many cancer types (Steinberg and Kemp, 2009). Two isoforms of AMPK exist including AMPK α1 and AMPK α2; however, discrimination between these isoforms for their involvement in certain diseases is currently not possible. en
dc.language.iso en -
dc.publisher ARMGHM - Atlas Génétique des Cancers -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; http://AtlasGeneticsOncology.org/Genes/PRKAA1ID43428ch5p13.html -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology en
dc.rights Open access resource - terms and conditions : http://irevues.inist.fr/utilisation -
dc.subject AMP-activated catalytic subunit alpha 1 en
dc.subject PRKAA1 en
dc.subject AMPK α1 en
dc.subject diabetes en
dc.subject neurodegenerative diseases en
dc.subject cancer en
dc.subject.classification Genes Section en
dc.subject.mesh AMP-Activated Protein Kinases/*metabolism en
dc.subject.mesh Animals en
dc.subject.mesh Anti-Inflammatory Agents/pharmacology/therapeutic use en
dc.subject.mesh Autophagy en
dc.subject.mesh *Enzyme Activation en
dc.subject.mesh Humans en
dc.subject.mesh Intestinal Absorption en
dc.subject.mesh Intestinal Diseases/drug therapy/*enzymology en
dc.subject.mesh Signal Transduction/drug effects en
dc.subject.mesh AMP-Activated Protein Kinases/genetics/*metabolism en
dc.subject.mesh Animals en
dc.subject.mesh Apoptosis/drug effects/genetics en
dc.subject.mesh Autophagy/*drug effects/genetics en
dc.subject.mesh Autophagy-Related Protein 5/genetics/metabolism en
dc.title PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) en
dc.type Article -
dc.contributor.affiliation Department of Biology, Middle East Technical University, 06800 Ankara, Turkey -
dc.identifier.doi https://doi.org/10.4267/2042/70205


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