PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1)

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URI: http://hdl.handle.net/2042/70205  |   DOI : https://doi.org/10.4267/2042/70205
Title: PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1)
Author: Seza, Esin Gülce; Güderer, Ismail; Ermis, Çagdas; Banerjee, Sreeparna
Abstract: Protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1), also known as AMPK α1, is an energy sensor that plays a key role in the regulation of cellular energy metabolism. AMPK α1 is the catalytic subunit of the heterotrimeric AMPK protein with a length of 548 amino acids. A key switch to activate this protein is an alteration in the AMP/ATP ratio. The protein is dysregulated in several human diseases including diabetes and metabolic syndrome, cardiovascular diseases, neurodegenerative diseases and many cancer types (Steinberg and Kemp, 2009). Two isoforms of AMPK exist including AMPK α1 and AMPK α2; however, discrimination between these isoforms for their involvement in certain diseases is currently not possible.
Subject: AMP-activated catalytic subunit alpha 1; PRKAA1; AMPK α1; diabetes; neurodegenerative diseases; cancer; Genes Section; AMP-Activated Protein Kinases/*metabolism; Animals; Anti-Inflammatory Agents/pharmacology/therapeutic use; Autophagy; *Enzyme Activation; Humans; Intestinal Absorption; Intestinal Diseases/drug therapy/*enzymology; Signal Transduction/drug effects; AMP-Activated Protein Kinases/genetics/*metabolism; Animals; Apoptosis/drug effects/genetics; Autophagy/*drug effects/genetics; Autophagy-Related Protein 5/genetics/metabolism
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2019

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