FZD5 (frizzled class receptor 5)

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dc.contributor.author Esposito, Ilaria -
dc.date.accessioned 2019-05-16T09:22:35Z
dc.date.available 2019-05-16T09:22:35Z
dc.date.issued 2019 -
dc.identifier.citation Ilaria, Esposito. FZD5 (frizzled class receptor 5). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2019, 4, p. 80-85 -
dc.identifier.issn 1768-3262 -
dc.identifier.uri http://hdl.handle.net/2042/70182
dc.description.abstract The Wnt signalling pathways are ways of signalling that transduce signals into cells through cell surface receptors; they are three different type of pathways and all of these are activated by binding a Wnt-protein ligand to a Frizzled family receptor. Frizzled is a family of G-protein coupled receptor proteins that works as receptor in the Wnt signalling pathway; when activated, Frizzled works activating the Dishevelled protein inside the cell, to transduce the signal. Frizzled-5 (FZD5) is part of this family and it is encoded by the FZD5 gene (located on the chr2, 2q33.3). Like all Frizzled members, FZD5 has an amino-terminal cysteine-rich domain (CRD) which allows the Wnt binding, seven-transmembrane domains and a cytoplasmic tail containing the PDZ domain binding motif at the carboxy-terminus. FZD5 shows an important role in development and it seems to be overexpressed in several types of cancer. FZD5 preferably binds WNT3A, WNT5A, WNT7A and WNT10B, activating both canonical and non-canonical pathways. en
dc.language.iso en -
dc.publisher ARMGHM - Atlas Génétique des Cancers -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; http://AtlasGeneticsOncology.org/Genes/FZD5ID47614ch2q33.html -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology en
dc.rights Open access resource - terms and conditions : http://irevues.inist.fr/utilisation -
dc.subject Wnt signalling pathway en
dc.subject FZD5 en
dc.subject Frizzled en
dc.subject Coloboma en
dc.subject.classification Genes Section en
dc.subject.mesh denocarcinoma/genetics/metabolism en
dc.subject.mesh Animals en
dc.subject.mesh Antibodies/*pharmacology en
dc.subject.mesh Carcinoma, Pancreatic Ductal/*genetics/metabolism en
dc.subject.mesh Cell Cycle Checkpoints/*drug effects en
dc.subject.mesh Cell Line, Tumor en
dc.subject.mesh Clustered Regularly Interspaced Short Palindromic Repeats en
dc.subject.mesh Colorectal Neoplasms/*genetics/metabolism en
dc.subject.mesh DNA-Binding Proteins/*genetics en
dc.subject.mesh Flow Cytometry en
dc.subject.mesh Fluorescent Antibody Technique en
dc.subject.mesh Frizzled Receptors/*antagonists & inhibitors/metabolism en
dc.subject.mesh Humans en
dc.subject.mesh Mice en
dc.subject.mesh Mice, SCI en
dc.title FZD5 (frizzled class receptor 5) en
dc.type Article -
dc.contributor.affiliation Department of Health Sciences, University of Milan, via A. Di Rudinò, 8 20142, Milan -
dc.identifier.doi https://doi.org/10.4267/2042/70182

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