B-cell lymphomas of presumed follicular origin include follicular lymphoma (FL), mantle cell lymphoma (MCL) and marginal zone lymphoma (MZL). Within the microenvironment of all these follicle-derived lymphomas tumor cells show a strict topographical and functional relationship with FDCs, together with reactive lymphoid and stromal cells. The FDC patterns, as described for FL and MCL, are reminiscent of the distribution pattern of FDC meshwork seen in the GC or the mantle zone of the secondary lymphoid follicle, respectively....