t(5;17)(q35;q21) NPM1/RARA

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dc.contributor.author Zamecnikova, Adriana -
dc.contributor.author al Bahar, Soad -
dc.date.accessioned 2018-11-22T07:54:05Z
dc.date.available 2018-11-22T07:54:05Z
dc.date.issued 2017 -
dc.identifier.citation Adriana, Zamecnikova ; Soad, al Bahar. t(5;17)(q35;q21) NPM1/RARA. Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2017, 12, p. 466-469 -
dc.identifier.issn 1768-3262
dc.identifier.uri http://hdl.handle.net/2042/69011
dc.description.abstract Acute promyelocytic leukemia (APL) is characterized by distinct clinical and biological features and by the reciprocal translocation t(15;17)(q22;q21)in the majority of patients. The translocation generates the fusion of the promyelocytic leukemia (PML) gene to the gene for retinoic acid receptor alpha (RARA) and these patients are responsive to differentiation treatment with all-trans retinoic acid (ATRA). Rare cases of patients with a morphological diagnosis of APL have variant chromosome translocations, which fuse RARA gene with partner genes other than PML, such as in the variant translocation t(5;17)(q35;q21) that fuses the N-terminus of nucleophosmin (NPM1) gene at 5q35 to the retinoic acid receptor alpha at 17q21. en
dc.language.iso en -
dc.publisher ARMGHM - Atlas Génétique des Cancers -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; http://AtlasGeneticsOncology.org/Anomalies/t517ID1081.html -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology en
dc.rights Open access resource - terms and conditions : http://irevues.inist.fr/utilisation -
dc.subject Chromosome 5 en
dc.subject chromosome 17 en
dc.subject Acute myeloid leukaemia en
dc.subject Acute promyelocytic leukemia en
dc.subject RARA en
dc.subject NPM1 en
dc.subject.classification Leukaemia Section en
dc.subject.mesh Cell Nucleolus/pathology/ultrastructure en
dc.subject.mesh Cell Nucleus/ultrastructure en
dc.subject.mesh Chromatin/pathology/ultrastructure en
dc.subject.mesh Exons/genetics en
dc.subject.mesh *Gene Fusion en
dc.subject.mesh Granulocyte Precursor Cells/cytology en
dc.subject.mesh Humans en
dc.subject.mesh Induction Chemotherapy en
dc.subject.mesh Leukemia, Promyelocytic, Acute/drug therapy/*genetics/*pathology en
dc.subject.mesh Magnetic Resonance Imaging en
dc.subject.mesh Male en
dc.subject.mesh Microscopy, Electron en
dc.subject.mesh Middle Aged en
dc.subject.mesh Nuclear Proteins/*genetics en
dc.subject.mesh Receptors, Retinoic Acid/*genetics en
dc.subject.mesh Retinoic Acid Receptor alpha en
dc.subject.mesh Reverse Transcriptase Polymerase Chain Reaction en
dc.subject.mesh Sarcoma, Myeloid/diagnosis/therapy en
dc.subject.mesh Tretinoin/therapeutic use en
dc.subject.mesh Aged en
dc.subject.mesh Antineoplastic Agents/*therapeutic use en
dc.title t(5;17)(q35;q21) NPM1/RARA en
dc.type Article -
dc.contributor.affiliation Kuwait Cancer Control Center, Department of Hematology -
dc.identifier.doi https://doi.org/10.4267/2042/69011


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