Acute myeloid leukemia with myelodysplasia related changes

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dc.contributor.author Nagy, Alexandra -
dc.contributor.author Neubauer, Andreas -
dc.date.accessioned 2018-11-22T07:53:58Z
dc.date.available 2018-11-22T07:53:58Z
dc.date.issued 2017 -
dc.identifier.citation Alexandra, Nagy ; Andreas, Neubauer. Acute myeloid leukemia with myelodysplasia related changes. Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2017, 11, p. 404-408 -
dc.identifier.issn 1768-3262
dc.identifier.uri http://hdl.handle.net/2042/68997
dc.description.abstract Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with two prominent features: i) hematopoietic progenitor cells loose the ability to differentiate normally and ii) the transformed leukemia cells show an impaired regulation of myeloid proliferation. AML with myelodysplasia-related changes is a sub-entity of AML that has a poor prognosis. It is characterized by a history of MDS, significant morphologic dysplasia, or MDS-related cytogenetic features such as -7/del(7q) and others. Whereas the prognosis of AML is quite different with respect to genetic aberrations, the therapy - except of acute promyelocytic leukemia (APL) - is still relatively unchanged from 30 years ago. Therefore, new treatment strategies are needed. en
dc.language.iso en -
dc.publisher ARMGHM - Atlas Génétique des Cancers -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; http://AtlasGeneticsOncology.org/Anomalies/AMLwithmyelodysplID2041.html -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology en
dc.rights Open access resource - terms and conditions : http://irevues.inist.fr/utilisation -
dc.subject Acute myeloid leukemia en
dc.subject multilineage dysplasia en
dc.subject myelodysplasia relatedchanges en
dc.subject.classification Leukaemia Section en
dc.subject.mesh Adult en
dc.subject.mesh Aged en
dc.subject.mesh Child, Preschool en
dc.subject.mesh Chromosomes, Human, Pair 11/*genetics en
dc.subject.mesh Female en
dc.subject.mesh Flow Cytometry en
dc.subject.mesh Gene Rearrangement en
dc.subject.mesh Histone-Lysine N-Methyltransferase/genetics en
dc.subject.mesh Humans en
dc.subject.mesh In Situ Hybridization, Fluorescence en
dc.subject.mesh Leukemia/*genetics en
dc.subject.mesh Male en
dc.subject.mesh Middle Aged en
dc.subject.mesh Myelodysplastic Syndromes/*genetics en
dc.subject.mesh Myeloid-Lymphoid Leukemia Protein/genetics en
dc.subject.mesh Retrospective Studies en
dc.subject.mesh Adult en
dc.subject.mesh Aged en
dc.subject.mesh Aged, 80 and over en
dc.subject.mesh Female en
dc.subject.mesh Flow Cytometry en
dc.title Acute myeloid leukemia with myelodysplasia related changes en
dc.type Article -
dc.contributor.affiliation Howard Hughes Medical Institute and the Department Pathology, Beckman Center for Molecular and Genetic Medicine, Stanford University, Stanford, California 94305, USA (A Na) -
dc.contributor.affiliation Dept. Internal Medicine and Hematology, Oncology and Immunology, Philipps University Marburg,Germany (A Ne) -
dc.identifier.doi https://doi.org/10.4267/2042/68997


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