Acute myeloid leukemia with myelodysplasia related changes

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Title: Acute myeloid leukemia with myelodysplasia related changes
Author: Nagy, Alexandra; Neubauer, Andreas
Abstract: Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with two prominent features: i) hematopoietic progenitor cells loose the ability to differentiate normally and ii) the transformed leukemia cells show an impaired regulation of myeloid proliferation. AML with myelodysplasia-related changes is a sub-entity of AML that has a poor prognosis. It is characterized by a history of MDS, significant morphologic dysplasia, or MDS-related cytogenetic features such as -7/del(7q) and others. Whereas the prognosis of AML is quite different with respect to genetic aberrations, the therapy - except of acute promyelocytic leukemia (APL) - is still relatively unchanged from 30 years ago. Therefore, new treatment strategies are needed.
Subject: Acute myeloid leukemia; multilineage dysplasia; myelodysplasia relatedchanges; Leukaemia Section; Adult; Aged; Child, Preschool; Chromosomes, Human, Pair 11/*genetics; Female; Flow Cytometry; Gene Rearrangement; Histone-Lysine N-Methyltransferase/genetics; Humans; In Situ Hybridization, Fluorescence; Leukemia/*genetics; Male; Middle Aged; Myelodysplastic Syndromes/*genetics; Myeloid-Lymphoid Leukemia Protein/genetics; Retrospective Studies; Adult; Aged; Aged, 80 and over; Female; Flow Cytometry
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2017

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