WNT10B (wingless-type MMTV integration site family)

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URI: http://hdl.handle.net/2042/68996  |   DOI : https://doi.org/10.4267/2042/68996
Title: WNT10B (wingless-type MMTV integration site family)
Author: Beghini, Alessandro; Lazzaroni, Francesca
Abstract: WNT10B is a member of the WNT ligand gene family encoding a secreted growth factor that has been reported to have role in a wide range of biological actions. Wnt10b was originally identified from mouse embryos and the virgin mammary gland, the locus was cloned by retroviral insertional activation, similar to the strategy used to identify other mammary oncogenes. During mammary gland development, Wnt10b seems to play a relevant role as it is the earliest expressed Wnt ligand. It has been well established that transgenic expression of Wnt10b in mouse mammary epithelial cells under the control of the MMTV promoter leads to mammary gland hyperplasia, increased proliferation, and branching. Furthermore, WNT10B has epistatic activity on HMGA2, which is necessary and sufficient for proliferation of triple-negative breast cancer. The role of Wnt10b in immune system was first described in helper T cells, and its expression in preB and proB cell lines suggested an involvement in lymphoid development. Furthermore, in CD8 T cells Wnt10b is induced by parathyroid hormone (PTH), suggesting that Wnt10b is playing an important role in T-cell development nad function. In a different study
Subject: WNT10B; Wnt Signaling Pathway; Leukemia; Breast Cancer; Genes Section
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2017

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