PGR (progesterone receptor)

Show simple item record Sherbet, Gajanan - 2018-11-22T07:53:56Z 2018-11-22T07:53:56Z 2017 -
dc.identifier.citation Gajanan, Sherbet. PGR (progesterone receptor). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2017, 11, p. 389-397 -
dc.identifier.issn 1768-3262
dc.description.abstract The progesterone receptor gene PGR is located on 11q22.1. The functional gene has 8 exons and 7 introns; the transcript is translated into 933 residues. The protein occurs as three isoforms viz. PR-A; PR-B; PR-C and 11 splice variants. PR-A and PR-B are structurally similar. The function of the splice variants is unclear, although some variants might be translated and others differentially expressed. The nuclear receptor PR isoforms are ubiquitously and uniformly expressed in target tissues. They may show differential expression in neoplasia with progressive changes. In the conventional pathway, PR undergoes conformational changes upon ligand interaction, translocates into the nucleus and binds PREs of responsive genes. PR can also function by non-genomic mode. It can activate the extra nuclear receptors, mPRs and PGRMC1 to influence cell proliferation and invasion via non-canonically routes. Both genomic and non-genomic modes of signaling may determine the relevance and the validity of PR in the progression, prognosis and management of breast cancer. The PR engages several systems, among them are PI3K/Akt/ MAPK and Wnt to influence cell adhesion, proliferation and apoptosis. The ER/PR axis is crucial in breast cancer, where the physiological outcome would be affected by the differential signaling initiated by the canonical andthe non-canonical receptors. The crosstalk between the ER/PR axis and the growth factor/PI3K/Akt/mTOR system is also highly relevant. PGR mutations and polymorp en
dc.language.iso en -
dc.publisher ARMGHM - Atlas Génétique des Cancers -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology en
dc.rights Open access resource - terms and conditions : -
dc.subject Apoptosis en
dc.subject Breast cancer en
dc.subject Cancer prevention en
dc.subject Cancer progression and prognosis en
dc.subject Canonical signalling en
dc.subject Cell adhesion en
dc.subject Cell proliferation en
dc.subject Extranuclear receptors en
dc.subject Growth factor/PI3K/Akt/ MAPK en
dc.subject Isoforms en
dc.subject mPRs en
dc.subject Non-genomic signalling en
dc.subject Ovarian cancer en
dc.subject Polymorphism en
dc.subject Progesterone antagonists/agonists en
dc.subject Progesterone receptor gene en
dc.subject PROGINS en
dc.subject Splice variants en
dc.subject Wnt signalling en
dc.subject.classification Genes Section en
dc.title PGR (progesterone receptor) en
dc.type Article -
dc.contributor.affiliation School of Electrical and Electronic Engineering, University of Newcastle Upon Tyne, Newcastle Upon Tyne UK and the Institute for Molecular Medicine, Huntington Beach CA, USA -

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