Mixed phenotype acute leukemia (MPAL)

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URI: http://hdl.handle.net/2042/68920  |   DOI : https://doi.org/10.4267/2042/68920
Title: Mixed phenotype acute leukemia (MPAL)
Author: Weinberg, Olga
Abstract: Mixed phenotype acute leukemia (MPAL) accounts for 2-5% of all acute leukemias (Weinberg OK et al., 2010)...e World Health Organization (WHO) classification of hematopoietic and lymphoid tumors proposed a simpler diagnostic algorithm, which relies on fewer and more lineage-specific markers to define MPAL. MPAL with t(9;22) and MLL rearrangement are now separate subtypes of MPAL and considered as distinct entities (Weir EG et al., 2010). Recent molecular studies demonstrates frequent epigenetic
Subject: Mixed phenotype acute leukemia; World Health Organization; Leukaemia Section; Adolescent; Adult; Clonal Evolution/genetics; Cluster Analysis; DNA (Cytosine-5-)-Methyltransferases/*genetics; Epigenesis, Genetic; Exome; Gene Expression Profiling; Gene Expression Regulation, Leukemic; High-Throughput Nucleotide Sequencing; Humans; Leukemia, Biphenotypic, Acute/*genetics/*metabolis
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2018

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