YEATS4 (YEATS domain containing 4)

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Title: YEATS4 (YEATS domain containing 4)
Author: Still, Ivan H; Lauffart, Brenda
Abstract: This entry reviews the structure, function and clinical significance of YEATS4, a gene originally identified from an amplicon on 12p15 found in a glioblastoma cell line and originally named glioma-amplified sequence (GAS41). The gene is amplified in several other cancers and translocations or rearrangements of chromosome 12 with breakpoints in YEATS4 are noted in such cancers as glioblastoma, lung cancer and soft tissue sarcomas. Several frameshift and one nonsense mutations have also been detec
Subject: YEATS4; glioblastoma; chromatin; centrosome; Genes Section; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic/*genetics/*metabolism; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Mice; Mice, Transgenic; Pancreatic Neoplasms/*genetics/*metabolism/pathology; *Signal Transduction; TCF Transcription Factors/*metabolism; Transcription Factors/*genetics; Tumor Stem Cell Assay; beta Catenin/*metabolism
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2018

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