t(1;5)(p32;q31) without TAL1 rearrangement

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URI: http://hdl.handle.net/2042/68911  |   DOI : https://doi.org/10.4267/2042/68911
Title: t(1;5)(p32;q31) without TAL1 rearrangement
Author: Zamecnikova, Adriana
Abstract: 1p32 translocations and submicroscopic interstitial deletions resulting in TAL1 deregulation are known aberrations in T lymphoblastic leukemia/lymphoma. The t(1;5)(p32;q31) is a rare translocation of 1p32 described only in 1 patient with aberrantly expressed TAL1 mRNA and protein (François et al., 1998) and in 2 other patients without involvement of the TAL1 gene.
Subject: chromosome 1; chromosome 5; 1p deletion; tumor supressor genes; TAL1; t(1;5)(p32;q31); Leukaemia Section; Basic Helix-Loop-Helix Transcription Factors/*genetics/metabolism; Bone Marrow/pathology; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 5; Humans; Karyotyping; Male; Middle Aged; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/genetics/pathology; Proto-Oncogene Proteins/*genetics/metabolism; T-Cell Acute Lymphocytic Leukemia Protein 1; Tomography, X-Ray Computed; *Translocation, Genetic; Adolescent
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2018

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