GRHL2 (grainyhead like transcription factor 2)

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Title: GRHL2 (grainyhead like transcription factor 2)
Author: Kars, Gizem; Muyan, Mesut
Abstract: A mammalian homolog of Drosophila Grainyhead protein, Grainyhead like 2 belongs to the Grainy Head-Like Proteins/CCAAT binding protein, GRH/CP2 family which is conserved from drosophila to mammals (Venkatesan, 2003)... mammals, there are 3 members of the family, GRHL1-3, the expression of which exhibit differential spatiotemporal expression patterns during development and in adult tissues. The GRHL family members are essential developmental transcription factors in epithelial cell morphogenesis/
Subject: GRHL2; Transcription factor; development; keratinocyte; differentiation; cancer; Genes Section; Carcinoma, Renal Cell/*genetics/pathology; Cell Line, Tumor; DNA-Binding Proteins/*genetics; Female; *Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Kidney/metabolism/*pathology; Kidney Neoplasms/*genetics/pathology; Male; Polymorphism, Single Nucleotide; Repressor Proteins/genetics; Transcription Factors/*genetic
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2018

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