t(2;17)(q32;q21) NABP1/RARA

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URI: http://hdl.handle.net/2042/68877  |   DOI : https://doi.org/10.4267/2042/68877
Title: t(2;17)(q32;q21) NABP1/RARA
Author: Zamecnikova, Adriana
Abstract: Acute promyelocytic leukemia (APL) is characterized by arrest of leukocyte differentiation at the promyelocyte stage. In classic APL, the central leukemia-initiating event is the chromosome translocation t(15;17)(q22;q21) resulting in the fusion of the retinoic acid receptor-alpha (RARA) gene on 17q21.1 with the promyelocytic leukemia..ML) gene at 15q24.1. In rare cases, RARA is fused with genes other than PML that gives rise to APL variants such as in der(2)t(2;17)(q32;q21) with the underlying
Subject: Variant; acute promyelocytic leukemia; RARA fusion genes; RARA; NABP1; NABP1/RARA; Leukaemia Section; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 2; Comparative Genomic Hybridization; DNA Breaks; DNA-Binding Proteins/*genetics; Gene Rearrangement/*genetics; Humans; Leukemia, Promyelocytic, Acute/*genetics/pathology; Male; Middle Aged; Oncogene Proteins, Fusion/*genetics; Receptors, Retinoic Acid/*genetics; Retinoic Acid Receptor alpha; Ataxia Telangiectasia Mutated Proteins; Cell Cycle/drug effects/radiation effects
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2018

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