HLTF (helicase-like transcription factor)

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dc.contributor.author Dhont, Ludovic -
dc.contributor.author Belayew, Alexandra -
dc.date.accessioned 2018-09-18T08:03:17Z
dc.date.available 2018-09-18T08:03:17Z
dc.date.issued 2017 -
dc.identifier.citation Ludovic, Dhont ; Alexandra, Belayew. HLTF (helicase-like transcription factor). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2017, 8, p. 279-287 -
dc.identifier.issn 1768-3262
dc.identifier.uri http://hdl.handle.net/2042/68527
dc.description.abstract HLTF is a transcription factor - The HLTF; Transcription factor; Post-replication DNA Repair; DNA damage tolerance pathways; E3-ubiquitin ligase; Cell Cycle; Cancer; Epigenetics; promoter methylation; Alternative splicing.Helicase-Like Transcription Factor (HLTF/SMARCA3) belongs to the family of SWI/SNF proteins that use the energy of ATP hydrolysis to remodel chromatin in a variety of cellular processes. Several groups independently isolated HLTF through its capacity to selectively interact with a DNA cis-element in the promoter or enhancer of different genes involved in cardiac development during embryogenesis, cell cycle, collagen biogenesis, cell motility and angiogenesis. HLTF is a key element in DNA Damage Tolerance pathways - HLTF plays a role in DNA Damage Tolerance, especially in (i) translesion synthesis and (ii) template switching pathways (fork regression and strand invasion). HLTF is an E3 ubiquitin ligase targeting PCNA (K164) that results in DTT activation. The E3 ubiquitin ligase, translocase and HIRAN catalytic domain are the HLTF core activities. A key role in DNA repair was confirmed in vivo, in 2 different Hltf null mouse models and showed that Hltf loss compromises error-free DNA replication and modulates mutagenesis by regulating proteins involved in the G2/M phase transition of the cell cycle in mouse heart and brain. HLTF is a tumor suppressor gene - In cancer, two mechanisms of HLTF inactivation are reported: (i) hypermethylation of its promoter and (ii) expression of truncated protein forms that have lost domains involved in DNA repair. These data support a role of tumor suppressor gene for HLTF. The first association between HLTF inactivation and tumorigenesis was shown when hypermethylation of the HLTF promoter was detected in 43% of primary colon tumors and 22-55% of gastric cancers. Moreover, HLTF deficiency in Apc-/+ mice induced the transition from colon adenocarcinoma to a carcinoma with high chromosomal instability. In head and neck, thyroid and uterus (cervix) cancers, an increased expression of two HLTF protein forms truncated in the carboxyl-terminal domain following alternative mRNA splicing was reported. These truncated HLTF forms have lost their DNA repair ability and might also have gained functions favouring cancer. en
dc.language.iso en -
dc.publisher ARMGHM - Atlas Génétique des Cancers -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; http://AtlasGeneticsOncology.org/Genes/HLTFID42332ch3q24.html -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology en
dc.rights Open access resource - terms and conditions : http://irevues.inist.fr/utilisation -
dc.subject HLTF en
dc.subject Transcription factor en
dc.subject Post-replication DNA Repair en
dc.subject DNA damage tolerance pathways en
dc.subject E3-ubiquitin ligase en
dc.subject Cell Cycle en
dc.subject Cancer en
dc.subject Epigenetics en
dc.subject promoter methylation en
dc.subject Alternative splicing en
dc.subject.classification Genes Section en
dc.subject.mesh Adaptor Proteins, Signal Transducing/genetics en
dc.subject.mesh Animals en
dc.subject.mesh Apoptosis Regulatory Proteins/genetics en
dc.subject.mesh Azoxymethane en
dc.subject.mesh Calcium-Calmodulin-Dependent Protein Kinases/genetics en
dc.subject.mesh Cell Adhesion Molecule-1 en
dc.subject.mesh Cell Adhesion Molecules en
dc.subject.mesh Colonic Neoplasms/chemically induced/*genetics en
dc.subject.mesh Connexins/genetics en
dc.subject.mesh Cyclin-Dependent Kinase Inhibitor p16/genetics en
dc.subject.mesh *DNA Methylation en
dc.subject.mesh DNA Modification Methylases/genetics en
dc.subject.mesh DNA Repair Enzymes/genetics en
dc.subject.mesh DNA-Binding Proteins/genetics en
dc.subject.mesh Death-Associated Protein Kinases en
dc.title HLTF (helicase-like transcription factor) en
dc.type Article -
dc.contributor.affiliation Molecular Biology, Health Institute, University of Mons, Mons, Belgium -
dc.identifier.doi https://doi.org/10.4267/2042/68527

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