t(2;11)(p21;q23) without KMT2A (MLL) rearrangement

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URI: http://hdl.handle.net/2042/68254  |   DOI : https://doi.org/10.4267/2042/68254
Title: t(2;11)(p21;q23) without KMT2A (MLL) rearrangement
Author: Ruano, Ana L; Shetty, Shashirekha
Abstract: Forty five cases carrying the t(2;11)(p21;q23) have been reported in the literature, mostly in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Some of these cases involve rearrangements of the the MLL gene (also known as KMT2A), on 11q23, which confers a more aggressive behavior in myeloid neoplasms. Several individual case reports, as well as series such as 19 cases reported by Bousquet et al., 2008 and 7 cases by Dvorak et al., 2014, describe myeloid neoplasms carrying the t(2;11)(p21;q23) without an MLL gene rearrangement, with possible prognostic implications. The authors of this paper describe two additional cases from their institution.
Subject: Myelodysplastic syndrome; acute myeloid leukemia; t(2;11); Leukaemia Section; Biopsy; Bone Marrow/metabolism/pathology; Chromosome Banding; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 2; DNA Mutational Analysis; *Exons; Humans; Janus Kinase 2/*genetics; MicroRNAs/*genetics; *Mutation; Myeloproliferative Disorders/diagnosis/*genetics; *Translocation, Genetic; Adult; Aged; *Chromosomes, Human, Pair 11
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2017

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