Nodular sclerosis classical Hodgkin lymphoma (NScHL)

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Title: Nodular sclerosis classical Hodgkin lymphoma (NScHL)
Author: Carbone, Antonino; Gloghini, Annunziata
Abstract: Over the past 50 years, a relevant progress has been made toward our understanding of classical Hodgkin lymphoma pathology and cell biology. Histologic classification evolved through different systems to the 2008 World. Nodular sclerosis is a subtype of classical Hodgkin lymphoma characterized by sclerosis, diagnostic Hodgkin and Reed-Sternberg cells and other tumour cells displaying a ""lacunar"" type morphology. The architectural pattern consists of grouped lacunar cells in lymphoid nodules surrounded by collagen bands. Nodular sclerosis classical Hodgkin lymphoma may have a cellular proliferation of fibroblasts, in addition to the sclerotic component. The amount of sclerosis varies markedly from case to case, from ample sclerosis (total sclerosis phase of nodular sclerosis) to a paucity of collagen associated with abundance of lacunar cells (cellular phase of nodular sclerosis) Health Organization classification, upgraded in 2016
Subject: nodular sclerosis subtype of Hodgkin Lymphoma; Hodgkin Lymphoma; classical Hodgkin lymphoma; microenvironment; clinics; pathology; genetics; Leukaemia Section; Genes, Neoplasm; Humans; Leukemia, Lymphoid/*classification/genetics/pathology; Lymphatic Diseases/classification/genetics/pathology; Lymphocytes/pathology; Lymphoma/*classification/genetics/pathology; Oncogene Proteins, Fusion/genetics; Paraproteinemias/classification/genetics/pathology; World Health Organization; Animals; B-Lymphocytes/pathology/virology; Cell Transformation, Viral
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2017

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