IRS2 (insulin receptor substrate 2)

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Title: IRS2 (insulin receptor substrate 2)
Author: Machado-Neto, Joao Agostinho; de Melo Campos, Paula; Traina, Fabiola
Abstract: Insulin receptor substrate 2 (IRS2) belongs to the insulin receptor substrate protein family and was initially discovered as an alternative route for signaling mediated by the insulin receptor. Currently, IRS2 has been well-established to mediate mitogenic and antiapoptotic signaling from several important cellular receptors. In the last years, many studies have indicated that IRS2 participates in the regulation of important biological processes involved in cancer phenotype, including cell proliferation, clonogenicity, metabolism and survival. The present review contains data on IRS2 DNA/RNA, protein encoded and function.
Subject: IRS2; mitogenic signaling; antiapoptotic signaling; Genes Section; Adenomatous Polyposis Coli Protein/genetics; Animals; Antineoplastic Agents/pharmacology/therapeutic use; Cell Line, Tumor; Cell Proliferation/drug effects; Colorectal Neoplasms/*drug therapy/immunology/metabolism/pathology; Macrophage Activation/drug effects; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy/*methods; Neoplasm Metastasis; Receptor, IGF Type 1/*metabolism; Receptor, Insulin/*metabolism
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2017

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