HIV-associated lymphomas

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Title: HIV-associated lymphomas
Author: Gloghini, Annunziata; Carbone, Antonino; Pantanowitz, Liron
Abstract: Lymphoma remains the most frequent neoplastic cause of death among HIV-infected individuals. Lymphomas in patients infected with HIV are heterogeneous, not only pathologically but also in terms of pathogenetic pathways and cellular derivation. This CARD summarizes the association of the different types of HIV-associated lymphomas with known genetic lesions and/or oncogenic viruses. In the setting of HIV infection different, but not mutually exclusive, pathogenic pathways might occur. For a distinct pathway of AIDS-related lymphomagenesis there can be multiple associated genetic lesions in the tumor. Several of the HIV-associated lymphomas are also related to EBV and/or KSHV (HHV-8) infection.
Subject: AIDS-related lymphoma; HIV-associated lymphoma; HIV; lymphoma; gamma herpesviruses; Leukaemia Section; Animals; B-Lymphocytes/pathology/virology; Cell Transformation, Viral; Clone Cells; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, gag; Germinal Center/virology; HIV/genetics/*pathogenicity; HIV Antigens/genetics/physiology; Humans; Immunocompromised Host; Lymphocyte Activation; Lymphoma, AIDS-Related/classification/*etiology/pathology/virology; Lymphoma, B-Cell/etiology/virology; Mice
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2017

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