TYRP1 (tyrosinase-related protein 1)

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URI: http://hdl.handle.net/2042/68125  |   DOI : https://doi.org/10.4267/2042/68125
Title: TYRP1 (tyrosinase-related protein 1)
Author: Ray, Kunal; Sengupta, Mainak; Ghosh, Sampurna
Abstract: TYRP1 gene, having a chromosomal location of 9p23, encodes a melanosomal enzyme belonging to the tyrosinase family. TYRP1 catalyses oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. TYRP1 is also thought to play a role in stabilizing tyrosinase and modulates its catalytic activity, in maintenance of melanosome structure, affecting melanocyte proliferation and melanocyte cell death. Defects in this gene cause oculocutaneous albinism type III; OCA III (also known as rufous oculocutaneous albinism).
Subject: TYRP1; albinism; OCA III; Genes Section; Adult; Aged; Aged, 80 and over; Base Sequence; Cell Line, Tumor; DNA Primers; Female; Genotype; Humans; Male; Melanoma/genetics/metabolism/*pathology; Membrane Glycoproteins/genetics/*metabolism; MicroRNAs/*genetics/metabolism; Middle Aged; Oxidoreductases/genetics/*metabolism
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2017

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