PARK7 (Parkinsonism associated deglycase)

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URI: http://hdl.handle.net/2042/66946  |   DOI : https://doi.org/10.4267/2042/66946
Title: PARK7 (Parkinsonism associated deglycase)
Author: La Cognata, Valentina; Cavallaro, Sebastiano
Abstract: PARK7 (also called DJ-1 or Parkinsonism associated deglycase) is a pleiotropic protein belonging to the peptidase C56 family. It acts as positive regulator of androgen receptor-dependent transcription, redox-sensitive chaperone, sensor for oxidative stress, and apparently protects neurons against oxidative stress and cell death. Dysfunctions in PARK7 are related to autosomal recessive early-onset Parkinson disease 7 and cancer forms. Here, we review some major data on PARK7, concerning the genetic structure, the transcription regulation, the encoded protein and functions, and its implication in human diseases.
Subject: PARK7; DJ-1; Autosomal Recessive Early-Onset Parkinson Disease; Oncogene; Genes Section; Cerebellar Diseases/*genetics/metabolism; DNA-Binding Proteins/*genetics/metabolism; Genes, myc; Humans; Intracellular Signaling Peptides and Proteins/*metabolism; Neoplasms/*genetics/metabolism; Neurodegenerative Diseases/genetics/metabolism; Oncogene Proteins/*metabolism; Parkinson Disease/*genetics/metabolism; Protein Deglycase DJ-1; Repressor Proteins/*metabolism; Retinitis Pigmentosa/*genetics/metabolism; Transcription Factors/*genetics/metabolism
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2016

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