RHOBTB1 (Rho-related BTB domain containing 1)

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URI:http://hdl.handle.net/2042/66084  |   DOI : 10.4267/2042/66084
Title: RHOBTB1 (Rho-related BTB domain containing 1)
Author:Schenkova, Kristina; Cai, Shuo; Rivero, Francisco
Abstract:RhoBTB1 is one of the three members of the RhoBTB family. All RhoBTB proteins are characterized by a GTPase domain followed by a proline-rich region, a tandem of two BTB domains and a C-terminal putative RING finger domain. RHOBTB1 is a putative tumour suppressor gene. Expression of RHOBTB1 has been found decreased in diverse tumors including kidney, breast, stomach and colon cancers and head and neck squamous cell carcinomas. RhoBTB1 is a component of Cullin 3-dependent ubiquitin ligase complexes but its role in tumorigenesis is unknown.
Subject:tumor suppressor; ubiquitin ligase; cullin 3; Genes Section; Cell Line; Cullin Proteins/genetics/*metabolism; GTP-Binding Proteins/genetics/*metabolism; HSP90 Heat-Shock Proteins/genetics/*metabolism; Humans; Immunoprecipitation; Mass Spectrometry; Protein Binding; Tumor Suppressor Proteins/genetics/*metabolism; Ubiquitin-Protein Ligases/genetics/*metabolism; Carcinogenesis/genetics; Cell Proliferation; Colonic Neoplasms/*genetics/pathology
Publisher:ARMGHM - Atlas Génétique des Cancers
Date:2016

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