Unbalanced whole-arm translocation der(1;10)(q10-q11;p10-p12)

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URI:http://hdl.handle.net/2042/66074  |   DOI : 10.4267/2042/66074
Title: Unbalanced whole-arm translocation der(1;10)(q10-q11;p10-p12)
Author:Zamecnikova, Adriana; Al Bahar, Soad
Abstract:Unbalanced whole-arm chromosome translocations (WAT) involving the long arm of chromosome 1 are relatively rare anomalies in hematologic malignancies. They may involve acrocentric chromosomes (e.g der(15)t(1;15)(q10;p10), der(21)t(1;21)(q10;p13) and der(22)t(1;22)(q10;p10) ) or telomeric regions of nonacrocentric chromosomes (e.g der(12)t(1;12) (q10;q24.3) and der(19)t(1;19)(q10;q13.4). The most common WAT of 1q to centromeric or pericentromeric regions of other recipient chromosomes (indicated as p10 or q10;p10 or q10) are the der(1;7), der(1;13), der(16)t(1;16) and der(19)t(1;19) that are non-randomly distributed among hematological malignancies. The derivatives of these translocations have been shown to give rise to a dicentric chromosome in a few cases (Sawyer et al., 1998; Fogu et al 2012).
Subject:chromosome 1; chromosome 10; hematologic malignancies; multiple myeloma; myeloid malignancies; Leukaemia Section; Aged; Chromosome Banding; Chromosomes, Human, Pair 1/*genetics; Chromosomes, Human, Pair 14/genetics; Female; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Myelodysplastic Syndromes/etiology/*genetics; Time Factors; *Translocation, Genetic; Adolescent; Adult; Child; Child, Preschool; Chromosomes, Human, Pair 16/*genetics; Chromosomes, Human, Pair 8/*genetics; Female; Humans; Infant; Infant, Newborn
Publisher:ARMGHM - Atlas Génétique des Cancers
Date:2016

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