HMGA2 (high mobility group AT-hook 2)

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URI: http://hdl.handle.net/2042/66056  |   DOI : https://doi.org/10.4267/2042/66056
Title: HMGA2 (high mobility group AT-hook 2)
Author: Wei, Jian-Jun
Abstract: HMGA2, the High Mobility Group A2 gene, is a non-histone and architectural transcription factor. As an oncofetal protein, HMGA2 plays an important role in development and contributes to the tumorigenesis of many epithelial and mesenchymal tumors. Upregulation of HMGA2 by non-random chromosomal translocations is common in mesenchymal tumors, whereas by the altered transcription regulation is likely the major mechanism in malignant epithelial tumors and it involves much more complex mechanisms. HMGA2 directly and indirectly regulates the multiple biological and oncogenic pathways. Its oncogenic property remains to be fully characterized.
Subject: HMGA2; Development; miRNA regulation; Stem cell self-renewal; transcription regulation; Oncofetal protein; neoplasia; Aging and senescence; epithelial-to-mesenchymal transition (EMT); non-random chromosomal translocation.; Genes Section; Breast Neoplasms/*pathology; Female; HMGA2 Protein/*physiology; Humans; MCF-7 Cells; Neoplasm Metastasis/*physiopathology; Phenotype; Receptor, PAR-1/*physiology; Vimentin/metabolism; Animals; Cell Transformation, Neoplastic/genetics/metabolism; Cystadenocarcinoma, Serous/*genetics/metabolism/*pathology; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; HMGA2 Protein/genetics/metabolism; Humans; Neoplasm Grading; Ovarian Neoplasms/*genetics/metabolism/*pathology; BRCA1 Protein/genetics; Cell Line, Transformed
Publisher: ARMGHM - Atlas Génétique des Cancers
Date: 2016

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