PIP4K2A is a lipid kinase that phosphorylates phosphatidylinositol (PtdIns) 5P, generating PtdIns4,5P2, which is an important precursor to second messengers of the phosphoinositide signal transduction pathways. Recently, studies have indicated that PIP4K2A is involved in the regulation of important biological processes that participate in the malignant phenotype, including cell proliferation, clonogenicity and survival. The present review on PIP4K2A contains data on DNA/RNA, protein encoded and where the gene is implicated....