SH3PXD2A (SH3 and PX domains 2A)

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dc.contributor.author Li, Carman Man-Chung -
dc.contributor.author Jacks, Tyler -
dc.date.accessioned 2017-10-13T09:25:25Z
dc.date.available 2017-10-13T09:25:25Z
dc.date.issued 2016 -
dc.identifier.citation Carman Man-Chung, Li ; Tyler, Jacks. SH3PXD2A (SH3 and PX domains 2A). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2016, 6, p. 326-330 -
dc.identifier.issn 1768-3262 -
dc.identifier.uri http://hdl.handle.net/2042/62941
dc.description.abstract The TKS5 protein, encoded by the gene SH3PXD2A, is a scaffolding protein essential for the formation of podosomes and invadopodia in untransformed cells and cancer cells, respectively. Podosomes and invadopodia (which collectively are termed invadosomes) are actin-rich cellular protrusions capable of secreting proteolytic enzymes that can degrade the extracellular matrix. These structures are thought to regulate cellular migration and invasion, as well as adhesion and the release of growth factors. In the context of cancer, TKS5-dependent invadopodia activity has been shown to play important roles in tumor growth and metastasis in various cancer types. Multiple isoforms of TKS5 exist due to alternative mRNA splicing and promoter usage. en
dc.language.iso en -
dc.publisher Jean-Loup Huret (Editor-in-Chief) -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology en
dc.rights Open access resource - terms and conditions : http://irevues.inist.fr/utilisation -
dc.subject SH3PXD2A en
dc.subject TKS5 en
dc.subject podosomes en
dc.subject invadopodia en
dc.subject metastasis en
dc.subject.classification Genes Section en
dc.subject.mesh Adenocarcinoma/genetics/mortality/*physiopathology en
dc.subject.mesh Animals en
dc.subject.mesh Animals, Genetically Modified en
dc.subject.mesh CDX2 Transcription Factor en
dc.subject.mesh Cell Line, Tumor en
dc.subject.mesh Gene Expression Regulation, Neoplastic/genetics en
dc.subject.mesh Gene Knockdown Techniques en
dc.subject.mesh Gene Silencing en
dc.subject.mesh Hepatocyte Nuclear Factor 3-beta/genetics/*metabolism en
dc.subject.mesh Homeodomain Proteins/genetics/*metabolism en
dc.title SH3PXD2A (SH3 and PX domains 2A) en
dc.type Article -
dc.contributor.affiliation David H. Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA -
dc.identifier.doi https://doi.org/10.4267/2042/62941


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