SH3PXD2A (SH3 and PX domains 2A)

Show full item record

Files in this item

PDF 08-2015-SH3PXD2AID45995ch10q24.pdf 369.0Kb

Pour citer ce document :
URI:http://hdl.handle.net/2042/62941  |   DOI : 10.4267/2042/62941
Title: SH3PXD2A (SH3 and PX domains 2A)
Author:Li, Carman Man-Chung; Jacks, Tyler
Abstract:The TKS5 protein, encoded by the gene SH3PXD2A, is a scaffolding protein essential for the formation of podosomes and invadopodia in untransformed cells and cancer cells, respectively. Podosomes and invadopodia (which collectively are termed invadosomes) are actin-rich cellular protrusions capable of secreting proteolytic enzymes that can degrade the extracellular matrix. These structures are thought to regulate cellular migration and invasion, as well as adhesion and the release of growth factors. In the context of cancer, TKS5-dependent invadopodia activity has been shown to play important roles in tumor growth and metastasis in various cancer types. Multiple isoforms of TKS5 exist due to alternative mRNA splicing and promoter usage.
Subject:SH3PXD2A; TKS5; podosomes; invadopodia; metastasis; Genes Section; Adenocarcinoma/genetics/mortality/*physiopathology; Animals; Animals, Genetically Modified; CDX2 Transcription Factor; Cell Line, Tumor; Gene Expression Regulation, Neoplastic/genetics; Gene Knockdown Techniques; Gene Silencing; Hepatocyte Nuclear Factor 3-beta/genetics/*metabolism; Homeodomain Proteins/genetics/*metabolism
Publisher:Jean-Loup Huret (Editor-in-Chief)
Date:2016

This item appears in the following Collection(s)

Show full item record





Advanced Search