CDC25A (Cell division cycle 25A)

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URI:http://hdl.handle.net/2042/62938  |   DOI : 10.4267/2042/62938
Title: CDC25A (Cell division cycle 25A)
Author:Dozier, Christine; Manenti, Stéphane
Abstract:CDC25A phosphatase is essential for cell cycle progression by activating the cyclin-associated kinases CDK4/6, CDK2 and CDK1. Its invalidation in mice is embryonic lethal. Its expression is tigthtly regulated at many levels and its overexpression is observed in various cancers, often associated with high grade tumors and poor prognosis.
Subject:cell cycle; CDK/cyclin; apoptosis; Genes Section; Biomarkers, Tumor/genetics/*metabolism; Blotting, Western; Child; Child, Preschool; Eye Enucleation; Female; Humans; Immunohistochemistry; Infant; Male; Prospective Studies; RNA, Messenger/genetics; RNA, Neoplasm/genetics; Retinal Neoplasms/*enzymology/pathology; Retinoblastoma/*enzymology/pathology
Publisher:Jean-Loup Huret (Editor-in-Chief)
Date:2016

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