CIC (capicua transcriptional repressor)

Show simple item record Firme, Marlo - Marra, Marco - 2017-10-04T12:02:06Z 2017-10-04T12:02:06Z 2016 -
dc.identifier.citation Marlo, Firme ; Marco, Marra. CIC (capicua transcriptional repressor). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2016, 5, p. 250-255 -
dc.identifier.issn 1768-3262 -
dc.description.abstract CIC is a tissue-specific transcriptional repressor that is highly conserved between metazoan organisms and is required for the normal development of multiple adult structures. CIC functions to transduce receptor tyrosine kinase (RTK) signalling into gene expression changes through a mechanism termed default repression, wherein CIC is bound to target gene promoters or enhancers and inhibits transcription in the absence of signal. This CIC-DNA interaction can be inhibited through activation of the RTK core signalling molecule mitogen-activated protein kinase (MAPK), which then allows for the transcription of CIC targets through this RTK-MAPK signalling axis. Components of RTK signalling are commonly dysregulated in cancers, possibly implying that CIC alterations observed in specific cancer types (e.g. oligodendroglioma and Ewing-like sarcomas) are a form of RTK signalling dysregulation that drives oncogenesis. CIC is also specifically expressed in cells of the developing central nervous system and its dysfunction is associated with the neurodegenerative disorder spinocerebellar ataxia type 1, implicating CIC in neuronal cell development and/or homeostasis. Other possible cellular and physiological roles for CIC include cell cycle control, ATP-citrate lyase phosphorylation, reactive oxygen species homeostasis, and bile acid homeostasis. en
dc.language.iso en -
dc.publisher Jean-Loup Huret (Editor-in-Chief) -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology en
dc.rights Open access resource - terms and conditions : -
dc.subject Oligodendroglioma en
dc.subject spinocerebellar ataxia type 1 en
dc.subject Ewing-like sarcoma en
dc.subject transcription factor en
dc.subject receptor tyrosine kinase en
dc.subject.classification Genes Section en
dc.subject.mesh Apoptosis en
dc.subject.mesh Carcinoma/*metabolism en
dc.subject.mesh Cell Line, Tumor en
dc.subject.mesh Cell Proliferation en
dc.subject.mesh DNA-Binding Proteins/metabolism en
dc.subject.mesh Disease Progression en
dc.subject.mesh Down-Regulation en
dc.subject.mesh Gene Expression Profiling en
dc.subject.mesh *Gene Expression Regulation, Neoplastic en
dc.subject.mesh Humans en
dc.subject.mesh Male en
dc.subject.mesh MicroRNAs/*metabolism en
dc.subject.mesh Microscopy, Fluorescence en
dc.subject.mesh Neoplasm Invasiveness en
dc.subject.mesh Prostatic Neoplasms/*metabolism en
dc.title CIC (capicua transcriptional repressor) en
dc.type Article -
dc.contributor.affiliation Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada (MF) -
dc.contributor.affiliation Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada (MM) -

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