CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5 (carcinoembryonic antigen))

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dc.contributor.author Shirasu, Naoto -
dc.contributor.author Kuroki, Masahide -
dc.date.accessioned 2017-10-04T12:02:06Z
dc.date.available 2017-10-04T12:02:06Z
dc.date.issued 2016 -
dc.identifier.citation Naoto, Shirasu ; Masahide, Kuroki. CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5 (carcinoembryonic antigen)). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2016, 5, p. 243-249 -
dc.identifier.issn 1768-3262 -
dc.identifier.uri http://hdl.handle.net/2042/62772
dc.description.abstract The CEACAM5 gene encodes carcinoembryonic antigen (CEA), which was first identified as an oncofetal antigen in 1965 in human colon cancer tissue extracts. CEA is a heavily glycosylated protein that belongs to the CEA-related cell adhesion molecule (CEACAM) family of the immunoglobulin (Ig) gene superfamily. CEA is closely related to CEACAM1, CEACAM3, CEACAM4, CEACAM5, CEACAM6, CEACAM7, and CEACAM8. CEA is also expressed at low levels in normal tissues of epithelial origin in a polarized manner and found only at the luminal portion of the cell, but not at the basolateral surface. CEA in normal tissues is now considered to protect the luminal organs of the body from microbial infection by binding and trapping infectious microorganisms. In contrast, the expression of CEA is frequently high in various carcinomas. Cancer cells not only lose polarized expression of CEA, but also actively cleave CEA from their surface by phospholipases, resulting in increased serum concentrations of CEA. The serum CEA levels may be monitored to detect a response to cancer therapy or disease recurrence and serve as a prognostic indicator in patients with various cancers, where elevated levels indicate a poor prognosis and correlate with a reduced overall survival. Cell-bound CEA has served as a target for tumor imaging and various cancer therapies. en
dc.language.iso en -
dc.publisher Jean-Loup Huret (Editor-in-Chief) -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology en
dc.rights Open access resource - terms and conditions : http://irevues.inist.fr/utilisation -
dc.subject CEACAM5 en
dc.subject CEA en
dc.subject CEA gene family en
dc.subject CD66e en
dc.subject tumor marker en
dc.subject.classification Genes Section en
dc.subject.mesh Cell Hypoxia/*immunology en
dc.subject.mesh Female en
dc.subject.mesh Hemorheology/*immunology en
dc.subject.mesh Humans en
dc.subject.mesh Hyperbaric Oxygenation/*methods en
dc.subject.mesh Male en
dc.subject.mesh Middle Aged en
dc.subject.mesh Anemia/blood/*immunology/parasitology en
dc.subject.mesh Animals en
dc.subject.mesh Cytokines/biosynthesis/*immunology en
dc.subject.mesh Interferon-gamma/immunology en
dc.subject.mesh Interleukin-10/immunology en
dc.subject.mesh Mice en
dc.subject.mesh Trypanosoma brucei brucei/*immunology en
dc.subject.mesh Trypanosomiasis, African/complications/*immunology/parasitology en
dc.subject.mesh Tumor Necrosis Factor-alpha/immunology en
dc.title CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5 (carcinoembryonic antigen)) en
dc.type Article -
dc.contributor.affiliation Department of Biochemistry, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan (NS) -
dc.contributor.affiliation Fukuoka University 5-16-47 Tamura, Sawara-ku, Fukuoka 814-0175, Japan (MK) -
dc.identifier.doi https://doi.org/10.4267/2042/62772


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