BRD3 (bromodomain containing 3)

Show simple item record Werner, Michael T - Hsu, Sarah C - Blobel, Gerd A - 2017-10-04T12:02:05Z 2017-10-04T12:02:05Z 2016 -
dc.identifier.citation Michael T, Werner ; Sarah C, Hsu ; Gerd A, Blobel. BRD3 (bromodomain containing 3). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2016, 5, p. 238-242 -
dc.identifier.issn 1768-3262 -
dc.description.abstract BRD3 is a ubiquitously expressed member of the bromodomain and extraterminal motif (BET) family of proteins that use their tandem N-terminal bromodomains to associate with acetylated histones and transcription factors. Translocations involving BRD3 and NUT generate oncogenic fusion proteins that drive NUT midline carcinoma (NMC), an aggressive squamous cell malignancy. In addition, small molecule inhibitors that target the bromodomain-acetyl lysine interaction of all BET proteins are in clinical development for both hematologic malignancies and diverse solid tumors. en
dc.language.iso en -
dc.publisher Jean-Loup Huret (Editor-in-Chief) -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology en
dc.rights Open access resource - terms and conditions : -
dc.subject.classification Genes Section en
dc.subject.mesh Animals en
dc.subject.mesh Cells, Cultured en
dc.subject.mesh Erythroid Cells/*metabolism en
dc.subject.mesh GATA1 Transcription Factor/genetics en
dc.subject.mesh *Gene Expression Regulation en
dc.subject.mesh Gene Knockdown Techniques en
dc.subject.mesh Hematopoiesis/*genetics en
dc.subject.mesh Humans en
dc.subject.mesh Mice en
dc.subject.mesh Protein Structure, Tertiary en
dc.subject.mesh Protein-Serine-Threonine Kinases/chemistry/*physiology en
dc.subject.mesh RNA-Binding Proteins/chemistry/*physiology en
dc.subject.mesh Alternative Splicing en
dc.subject.mesh Cell Line en
dc.subject.mesh *Databases, Protein en
dc.title BRD3 (bromodomain containing 3) en
dc.type Article -
dc.contributor.affiliation Division of Hematology, Childrens Hospital of Philadelphia, Philadelphia, PA, United States (MTW, SCH, GAB) -
dc.contributor.affiliation Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States (MTW, SCH) -

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