BRD3 (bromodomain containing 3)

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Title: BRD3 (bromodomain containing 3)
Author: Werner, Michael T; Hsu, Sarah C; Blobel, Gerd A
Abstract: BRD3 is a ubiquitously expressed member of the bromodomain and extraterminal motif (BET) family of proteins that use their tandem N-terminal bromodomains to associate with acetylated histones and transcription factors. Translocations involving BRD3 and NUT generate oncogenic fusion proteins that drive NUT midline carcinoma (NMC), an aggressive squamous cell malignancy. In addition, small molecule inhibitors that target the bromodomain-acetyl lysine interaction of all BET proteins are in clinical development for both hematologic malignancies and diverse solid tumors.
Subject: Genes Section; Animals; Cells, Cultured; Erythroid Cells/*metabolism; GATA1 Transcription Factor/genetics; *Gene Expression Regulation; Gene Knockdown Techniques; Hematopoiesis/*genetics; Humans; Mice; Protein Structure, Tertiary; Protein-Serine-Threonine Kinases/chemistry/*physiology; RNA-Binding Proteins/chemistry/*physiology; Alternative Splicing; Cell Line; *Databases, Protein
Publisher: Jean-Loup Huret (Editor-in-Chief)
Date: 2016

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