t(4;10)(q12;q23) PDGFRA/TNKS2

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URI:http://hdl.handle.net/2042/62673  |   DOI : 10.4267/2042/62673
Title: t(4;10)(q12;q23) PDGFRA/TNKS2
Author:Chalmers, Zachary R; Frampton, Garrett M; Ali, Siraj M; OhgamI, Robert; Miles, Curtis R
Abstract:Comprehensive genomic profiling identifies a novel PDGFRA-TNKS2 gene fusion in a female case of myeloid neoplasm with eosinophilia. The patient was treated with imatinib, and showed a dramatic and ongoing response with no evidence of disease
Subject:PDGFRA; TNKS2; fusion gene; chronic myeloproliferative disease; eosinophilia.; Leukaemia Section; Benzamides/administration & dosage; Eosinophilia/drug therapy/genetics/pathology; Female; Genome, Human; High-Throughput Nucleotide Sequencing; Humans; Hypereosinophilic Syndrome/drug therapy/*genetics/pathology; Imatinib Mesylate; Leukemia; Middle Aged; Myeloproliferative Disorders; Oncogene Proteins, Fusion/*genetics/isolation & purification
Publisher:Jean-Loup Huret (Editor-in-Chief)
Date:2016

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