MECOM (Ecotropic Viral Integration Site 1 (EVI1) and Myelodysplastic Syndrome 1 (MDS1-EVI1)

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Title: MECOM (Ecotropic Viral Integration Site 1 (EVI1) and Myelodysplastic Syndrome 1 (MDS1-EVI1)
Author: Wieser, Rotraud
Abstract: The MECOM locus in chromosome band 3q26.2 gives rise to two major mRNA and protein species, EVI1 and MDS1/EVI1, of which the former has been characterized far more extensively. EVI1 has been implicated in the maintenance and expansion of normal hematopoietic stem cells. In addition, it plays a role as an oncogene in myeloid leukemia and in certain solid tumors, its overexpression being associated with a dismal prognosis in several of these malignancies. EVI1 exerts its biological effects mainly by regulating gene transcription, and does so by acting as a sequence specific transcription factor, by modulating the activity of other sequence specific transcription factors, and by regulating promoter CpG island methylation.
Subject: Transcription regulation; myeloid leukemia; therapy resistance; hematopoietic stem cells; Genes Section; *Apoptosis; Biomarkers, Tumor/genetics/metabolism; Case-Control Studies; Cell Proliferation; Chromatin Immunoprecipitation; DNA-Binding Proteins/genetics/*metabolism; Flow Cytometry; Gene Expression Profiling; *Gene Expression Regulation, Leukemic; Humans; Immunoenzyme Techniques; Leukemia, Lymphocytic, Chronic, B-Cell/*genetics/*mortality/pathology; MicroRNAs/*genetics; Oligonucleotide Array Sequence Analysis; Prognosis; Proto-Oncogene Proteins/genetics/*metabolism; Proto-Oncogenes/genetics; RNA, Messenger/genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction
Publisher: Jean-Loup Huret (Editor-in-Chief)
Date: 2016

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