LATS1 (Large Tumor Suppressor 1)

Show simple item record Visser-Grieve, Stacy - van Rensburg, Helena J Janse - Yang, Xiaolong - 2017-09-25T12:55:35Z 2017-09-25T12:55:35Z 2016 -
dc.identifier.citation Stacy, Visser-Grieve ; Helena J Janse, van Rensburg ; Xiaolong, Yang. LATS1 (Large Tumor Suppressor 1). Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2016, 4, p. 179-184 -
dc.identifier.issn 1768-3262
dc.description.abstract LATS1 tumor suppressor is a serine/threonine kinase of the AGC kinase family and a core component of the Hippo pathway in mammals. LATS1 regulates various biological processes such as cell cycle progression, genetic stability, cell motility and adhesion, apoptosis, stem cell renewal and differentiation (Visser and Yang, 2010; Mo et al., 2014). LATS1 performs these functions by phosphorylating various substrates such as transcriptional co-activators YAP and TAZ (Zhao et al., 2007; Hao et al., 2008). LATS1 is also required for tissue homeostasis in both flies and mice (Visser et al., 2010). In addition to its roles in a broad spectrum of normal biological processes, loss of LATS1 has been shown to be important for the development of cancer and resistance to chemotherapeutic drugs (Visser et al., 2010). Therefore, understanding the molecular mechanisms underlying loss-of-LATS1-induced tumorigenesis and drug resistance will shed light on the design of new cancer treatment strategies in the future. en
dc.language.iso en -
dc.publisher Jean-Loup Huret (Editor-in-Chief) -
dc.relation Atlas of Genetics and Cytogenetics in Oncology and Haematology ; -
dc.relation.ispartofseries Atlas of Genetics and Cytogenetics in Oncology and Haematology en
dc.rights Open access resource - terms and conditions : -
dc.subject.classification Genes Section en
dc.subject.mesh Adenocarcinoma, Clear Cell/*metabolism en
dc.subject.mesh Adult en
dc.subject.mesh Aged en
dc.subject.mesh Biomarkers, Tumor/metabolism en
dc.subject.mesh Female en
dc.subject.mesh Humans en
dc.subject.mesh Immunohistochemistry/methods en
dc.subject.mesh Long-Acting Thyroid Stimulator/*metabolism en
dc.subject.mesh Middle Aged en
dc.subject.mesh Neoplasm Recurrence, Local/diagnosis/metabolism en
dc.subject.mesh Ovarian Neoplasms/*metabolism en
dc.subject.mesh Protein-Serine-Threonine Kinases/*metabolism en
dc.subject.mesh Tumor Suppressor Proteins/*metabolism en
dc.subject.mesh Alphapapillomavirus/*pathogenicity en
dc.subject.mesh Base Sequence en
dc.subject.mesh Cell Cycle en
dc.subject.mesh DNA Primers en
dc.subject.mesh Female en
dc.subject.mesh HEK293 Cells en
dc.subject.mesh HeLa Cells en
dc.subject.mesh Humans en
dc.title LATS1 (Large Tumor Suppressor 1) en
dc.type Article -
dc.contributor.affiliation Department of Pathology and Molecular Medicine, Queen's University Kingston, ON, Canada -

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