DUSP26 (dual specificity phosphatase 26)

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URI:http://hdl.handle.net/2042/62667  |   DOI : 10.4267/2042/62667
Title: DUSP26 (dual specificity phosphatase 26)
Author:Panni, Simona; Gallo, Raffaella
Abstract:The DUSP26 gene encodes for an atypical dual specificity phosphatase commonly referred to as Dusp26 or MPK8. Although its physiological role is poorly understood, different substrates have been reported to be dephosphorylated by Dusp26, including p53, Kif3, Erk and p38. In this report we summarize the current knowledge on DUSP26 gene, its transcripts, the encoded protein and its function in normal and tumorous tissues. Notably, the phosphatase is overexpressed in neuroblastoma and ATC cells, where it promotes chemoresistance by inhibiting the p53 and the p38 proteins, respectively. Dusp26 represents a promising novel therapeutic target to be integrated with others and with conventional medicine, to improve survival outcome in patients and to reduce toxicity.
Subject:DUSP26; dual-specificity phosphatase; MKP; phosphopeptides; MAPK; Genes Section; Dual Specificity Phosphatase 3/*metabolism; Humans; Mitogen-Activated Protein Kinases/metabolism; Neoplasms/enzymology/metabolism; Signal Transduction/physiology; *Databases, Nucleic Acid; *Genes, Neoplasm
Publisher:Jean-Loup Huret (Editor-in-Chief)
Date:2016

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