SCD (stearoyl-CoA desaturase (delta-9-desaturase))

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Title: SCD (stearoyl-CoA desaturase (delta-9-desaturase))
Author: Mehdizadeh, Amir; Fayezi, Shabnam; Darabi, Masoud
Abstract: Despite the presence of monounsaturated fatty acids (MUFA) in the usual diet, these fatty acids may also be synthesized de novo from saturated fatty acids (SFA) through enzymatic desaturase activity (Arregui et al., 2012). Stearoyl-CoA desaturase (SCD)1 and SCD5 isozymes have been identified in human. SCD1 or ?9 desaturase is predominantly expressed in adipose tissue, meibomian, harderian and preputial glands. This enzyme is highly induced in response to high carbohydrate diet (Mauvoisin & Mounier, 2011). It has been proven that the elevated levels of SCD1 are associated with obesity, metabolic disorders and malignancies. Altogether, these findings propose SCD1 as a new therapeutic target.
Subject: Stearoyl-CoA desaturase 1; monounsaturated fatty acids; saturated fatty acids; Genes Section; Cell Line, Tumor; Flavonoids/pharmacology; Humans; MAP Kinase Signaling System/*drug effects/physiology; PPAR delta/*agonists; Pancreatic Neoplasms/*metabolism; Stearoyl-CoA Desaturase/*drug effects; Thiazoles/pharmacology; 1-Naphthylamine/analogs & derivatives/chemistry; Adult; Aged; Choline Kinase/analysis/metabolism; Fatty Acid Synthases/analysis/metabolism; Fatty Acids, Monounsaturated/analysis/*metabolism; Fatty Acids, Unsaturated/analysis/*metabolism; Female; Gentisates/chemistry; Huma
Publisher: Jean-Loup Huret (Editor-in-Chief)
Date: 2016

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