FAM107B (family with sequence similarity 107, member B)

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URI: http://hdl.handle.net/2042/62513  |   DOI : https://doi.org/10.4267/2042/62513
Title: FAM107B (family with sequence similarity 107, member B)
Author: Nakajima, Hideo; Koizumi, Keita
Abstract: FAM107 members contain an N-terminal domain of unknown function (DUF1151) that is conserved across species. Mammals have two genes, FAM107A and FAM107B, which expressions are strong in neural cells, whereas their expressions are mostly down-regulated in cancer cells. Both proteins appear to alter cytoskeleton rearrangements and are involved in cell migration and invasion. The molecular mechanisms underlying the diverse biological functions of FAM107 remain unclear, while it shows functional similarity with heat-shock proteins (HSPs) as well as reactions to cellular stress.
Subject: tumor suppressor gene; heat-shock protein; neuron; Genes Section; A Kinase Anchor Proteins/*genetics/physiology; Child; Child Development Disorders, Pervasive/*genetics; Female; Genes/genetics; Genetic Predisposition to Disease/genetics; Genome-Wide Association Study; Humans; Male; Adolescent; Adult; Age Factors; Brain/*metabolism/pathology; Case-Control Studies; *DNA Methylation; Depressive Disorder, Major/*genetics/metabolism; *Epigenesis, Genetic; Female; Flow Cytometry; Genetic Markers; Humans
Publisher: Jean-Loup Huret (Editor-in-Chief)
Date: 2016

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