DLG1 (discs, large homolog 1 (Drosophila))

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URI: http://hdl.handle.net/2042/62512  |   DOI : https://doi.org/10.4267/2042/62512
Title: DLG1 (discs, large homolog 1 (Drosophila))
Author: Massimi, Paola; Banks, Lawrence
Abstract: The human homologue of Drosophila disc large tumor suppressor protein (hDlg) also known as synapse-associated protein 97, is a scaffold protein, a member of the membrane-associated guanylate kinase family. It is one of the proteins known to act cooperatively in regulating cell polarity and proliferation, suggesting an important connection between epithelial organization and cellular growth control. An abnormal expression of hDlg has been reported in several cancer types.This protein may have a role in cell junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation.
Subject: Polarity; cell junctions; tumour progression; Genes Section; Adaptor Proteins, Signal Transducing/metabolism; Amino Acid Sequence; DNA-Binding Proteins/chemistry/genetics/*metabolism; Female; Humans; Membrane Proteins/metabolism; Oncogene Proteins, Viral/chemistry/genetics/*metabolism; PDZ Domains/*genetics; Papillomavirus Infections/*complications/genetics/metabolism; Phosphorylation; Protein Binding; Protein Interaction Domains and Motifs/genetics; Repressor Proteins/chemistry/genetics/*metabolism; Uterine Cervical Neoplasms/complications/genetics/*viro
Publisher: Jean-Loup Huret (Editor-in-Chief)
Date: 2016

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