Head and Neck: Primary oral mucosal melanoma

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URI: http://hdl.handle.net/2042/62511  |   DOI : https://doi.org/10.4267/2042/62511
Title: Head and Neck: Primary oral mucosal melanoma
Author: Coutinho-Camillo, Claudia Malheiros; Lourenço, Silvia Vanessa; Soares, Fernando Augusto
Abstract: Primary Oral Mucosal Melanoma (POMM) is an aggressive and rare disease that involves mostly the hard palate and upper gingiva, followed by mandibular gingiva, lip mucosa, and other oral sites. POMM develops primarily between the 5th and 8th decades of life and most studies report a similar distribution between males and females. In contrast to cutaneous melanomas, the risk factors and pathogenesis are poorly understood. However, genetic profiling of mucosal melanomas have identified a number of altered genes, such as KIT, BRAF and N-RAS, suggesting that molecular pathways like the mitogen activated protein kinase (MAPK) pathway (RAS/MEK/ERK) and the phosphotidylinositol-3-kinase-PTEN pathway (PI3K/AKT/PTEN/mTOR) might be used for potential targeted therapy.
Subject: Mucosal Melanoma; Head and Neck; Tumors Section; Combined Modality Therapy; Head and Neck Neoplasms/mortality/pathology/*therapy; Humans; Melanoma/mortality/pathology/*therapy; Mouth Neoplasms/therapy; Neoplasm Recurrence, Local/prevention & control; Neoplasm Staging; Nose Neoplasms/therapy; Paranasal Sinus Neoplasms/therapy; Prognosis; Risk Factors; Treatment Outcome; Gastrointestinal Neoplasms/genetics/pathology/*therapy; Head and Neck Neoplasms/genetics/pathology/*therapy; Humans; Melanoma/genetics/pathology/*therapy; Mucous Membrane/*p
Publisher: Jean-Loup Huret (Editor-in-Chief)
Date: 2016

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