SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))

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URI: http://hdl.handle.net/2042/62507  |   DOI : https://doi.org/10.4267/2042/62507
Title: SIRT1 (sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae))
Author: Chen, WenYong
Abstract: SIRT1 is a member of the mammalian sirtuin genes that encode for seven protein lysine modifiers with deacetylase, ADP-ribosyltransferase and other deacylase activities. SIRT1 plays diverse roles in regulating cell proliferation, differentiation, stress response, metabolism, energy homeostasis, aging and cancer. Besides deacetylating histone substrates, SIRT1 regulates functions of an array of non-histone proteins including transcriptional factors for gene regulation, DNA repair machinery elements for reducing catastrophic genome lesions, epigenetic factors for chromatin and gene regulation, nuclear receptors and circadian clock as well as related factors for metabolism, and other cell signaling molecules. SIRT1 is involved in many types of human cancer.
Subject: Genes Section; Animals; Antigens, CD34/metabolism; Benzothiazoles/pharmacology; Cell Proliferation/drug effects; Cell Survival/drug effects; Drug Resistance, Neoplasm/drug effects/*genetics; Gene Duplication/drug effects; Gene Knockdown Techniques; *Gene Regulatory Networks; Humans; Leukemia, Myeloid, Acute/enzymology/*genetics/pathology; Mice, SCID; Neoplastic Stem Cells/drug effects/enzymology/*pathology; Phenylurea Compounds/pharmacology; Protein Binding/drug effects; Proto-Oncogene Proteins c-myc/*genetics
Publisher: Jean-Loup Huret (Editor-in-Chief)
Date: 2016

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