CHFR (Checkpoint with fork-head associated and ring finger)

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Title: CHFR (Checkpoint with fork-head associated and ring finger)
Author: Erson-Bensan, Ayse E; Begum Akman, Hesna; Petty, Elizabeth M
Abstract: Growing evidence in mice, primary human tumors, and mammalian cell culture models indicate that CHFR may function as a potent tumor suppressor. CHFR functions as part of an early G2/M checkpoint, more specifically in antephase. Antephase refers to late G2 when chromosome condensation starts. This early mitotic checkpoint causes a delay in chromosome condensation in response to mitotic stresses. The human CHFR gene was originally identified during a search for novel cell cycle checkpoint proteins that have fork-head associated domains. Initial analysis indicated that the CHFR-associated G2/M checkpoint was inactivated in a subset of cancers as demonstrated by high mitotic indices (a high percentage of cells that have condensed chromosomes) in response to exposure to the microtubule poison, nocodazole, due to lack of CHFR expression or CHFR mutations in various cancers. Many other studies showed promoter hypermethylation leading to low/no expression of CHFR.
Subject: CHFR; cell cycle; checkpoint; antephase; Genes Section; Aged; Cell Cycle Proteins/*genetics; Colorectal Neoplasms/*genetics/mortality/pathology; *CpG Islands; *DNA Methylation; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Male; *Microsatellite Instability; Middle Aged; Mutation/*genetics; Neoplasm Proteins/*genetics; Neoplasm Staging; Phenotype; Prognosis; Promoter Regions, Genetic/*genetics; Prospective Studies; Survival Rate; Adaptor Proteins, Signal Transducing/*genetics
Publisher: Jean-Loup Huret (Editor-in-Chief)
Date: 2016

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